Why is NAD⁺ becoming a central focus in aging research?

Aging doesn’t start with visible wrinkles or loss of firmness. It begins much earlier—at the cellular level. Because of this, modern research is shifting its focus toward the molecular systems that regulate how cells produce energy, repair damage, and adapt to stress. At the justify of these processes is NAD⁺, a molecule essential for the function of every living cell.

What is NAD⁺ and why does it matter?

NAD⁺ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme present in all living cells. Without it, two fundamental processes cannot function efficiently:

• cellular energy production
• cellular repair and regeneration

Its biological role can be understood through two core functions:

1. Energy production: NAD⁺ plays a critical role in converting nutrients into usable cellular energy (ATP).
2. DNA repair and cellular regulation: It supports key enzymes such as PARPs and sirtuins, which are responsible for maintaining genetic stability, regulating stress responses, and supporting long-term cellular function.

How does NAD⁺ support cellular energy?

Every time the body processes nutrients, electrons are released. NAD⁺ captures these electrons and transforms into NADH, transporting them to the mitochondria—the cell’s energy justifys. There, ATP is produced, providing immediate energy for cellular processes. After releasing the electrons, NADH converts back into NAD⁺, and the cycle continues. When NAD⁺ levels are optimal, energy production remains efficient. When they decline, it can affect multiple biological processes:

• slower cellular regeneration
• reduced collagen production
• decreased skin renewal
• lower physical and mental energy levels

NAD⁺ and DNA repair: why it matters for skin

Daily exposure to UV radiation, pollution, and oxidative stress doesn’t just affect the surface of the skin—it can also damage cellular DNA. The body is capable of repairing this damage, but these mechanisms rely heavily on NAD⁺ availability. PARP enzymes, which play a direct role in DNA repair, consume NAD⁺ during their activity. At the same time, sirtuins—often associated with longevity—use NAD⁺ to regulate inflammation, stress response, and cellular stability.

From a skin perspective, this is essential.
Healthy DNA function is the foundation of proper cell division and balanced regeneration.

What happens when NAD⁺ levels decline?

NAD⁺ levels naturally decrease with age. Research suggests that this decline can begin as early as the late 30s, with levels dropping by up to 30–50% by midlife.

This shift is gradual and influenced by:

• oxidative stress
• low-grade chronic inflammation
• reduced internal NAD⁺ production

At the same time, the body requires more NAD⁺ to maintain repair processes.

As availability decreases, cellular efficiency declines. Over time, this may contribute to visible and functional changes:

• slower regeneration
• uneven skin tone
• reduced elasticity
• more persistent fine lines
• increased sensitivity and slower barrier recovery

The skin, as a constantly renewing and energy-demanding organ, reflects these changes particularly quickly.

Supporting NAD⁺: a new direction in skincare

Understanding NAD⁺ has reshaped the way we approach skincare. The focus is no longer only on correcting visible signs, but on supporting the biological processes that maintain skin function over time. However, incorporating NAD⁺ into formulations is not straightforward. The molecule is inherently unstable, which makes effective concentrations difficult to achieve.

Typical concentration ranges:

• 0.005–0.02% → minimal biological relevance
• 0.03–0.05% → moderate support
• 0.07–0.1% → effective, professional-level range
• above 0.15% → advanced biotechnological formulations

DermaGene NAD⁺ Radiant Longevity Serum

The DermaGene NAD+ Radiant Longevity Serum was developed with a clear objective: to support skin function at the cellular level. The formula contains 0.08% NAD⁺, placing it within the professional-use concentration range.

Its lightweight, fast-absorbing texture allows easy integration into daily routines, while remaining compatible with advanced treatment methods such as:

• microneedling
• ultrasound
• radiofrequency

In addition to NAD⁺, the formula includes complementary actives that support regeneration:

• PDRN (1000 ppm) – supports tissue renewal
• Copper Tripeptide-1 (GHK-Cu) – helps maintain skin structure and elasticity
• 0.5% resveratrol – antioxidant protection
• Panthenol + hyaluronic acid – hydration and barrier comfort

Final perspective

NAD⁺ is not a “miracle ingredient.” It is something more fundamental: a core requirement for balanced cellular function.

As levels decline, it reflects a gradual shift in how efficiently cells produce energy, repair damage, and maintain stability. Supporting these processes—both topically and from within—represents a more advanced, biology-driven approach to skin longevity.