Selected clinical and laboratory research
Stirling & Haslam, 2007 — randomized, double-blind, placebo-controlled 1072 nm trial
With daily treatment for 6–8 weeks, 52–57% of volunteers reported improvement in fine lines and wrinkles in the treated eye area. This was a self-reported study using a different device; the percentage describes volunteers reporting improvement, not the size of wrinkle reduction.
Mota et al., 2023 — randomized 660 nm photobiomodulation trial
Ten sessions over four weeks produced a 31.6% reduction in periocular wrinkle volume on the red-light side. Hydration and viscoelasticity did not significantly improve in this study.
Bragato et al., 2025 — randomized, sham-controlled 660 nm LED mask study
Two or three weekly sessions for four weeks significantly reduced selected glabellar and periorbital wrinkle measurements compared with sham treatment.
Wunsch & Matuschka, 2014 — controlled red and near-infrared photobiomodulation study
Repeated treatments improved complexion, skin feeling, measured roughness and ultrasonographically measured collagen density compared with controls.
Mineroff et al., 2023 — 633 / 830 / 1072 nm home LED mask study
After six weeks, participants reported improvements in fine lines and wrinkles, texture and youthful appearance; digital analysis showed favorable changes in wrinkles, UV spots, brown spots, pores and porphyrins.
Ershadi & Barbieri, 2025 — systematic review of at-home LED devices for acne
The review found evidence that at-home red and/or blue LED devices can improve inflammatory and non-inflammatory acne lesion counts, while noting variation between devices and study protocols.
Lee et al., 2007 — randomized, placebo-controlled red / NIR LED study
Human skin biopsies showed increased collagen and elastic fibres and activated fibroblasts after treatment with 633 nm, 830 nm or their combination.
Barolet et al., 2009 — 660 nm LED laboratory study with a clinical component
Reconstructed human skin showed increased type I procollagen and reduced MMP-1 compared with unexposed tissue. These molecular findings are laboratory results, not a measured percentage of visible improvement in NeuroCalm users.
Evidence note: These publications support the use of relevant LED wavelengths and treatment concepts. They did not test NeuroCalm itself, and their outcomes should not be read as guaranteed product-specific results.